Majd Zayzafoon Selected Research

1- ((N- (2,3,4,5,6- pentafluorocinnamoyl)- O- (2,6- dichlorobenzyl))tyrosyl)- 4- (bis(diethoxyphosphono))methylaminiopiperidine

10/2008

BKM1740, an acyl-tyrosine bisphosphonate amide derivative, inhibits the bone metastatic growth of human prostate cancer cells by inducing apoptosis.

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Majd Zayzafoon Research Topics

Disease

14	Neoplasms (Cancer) 01/2017 - 09/2006
11	Prostatic Neoplasms (Prostate Cancer) 03/2016 - 01/2004
8	Neoplasm Metastasis (Metastasis) 03/2016 - 04/2007
4	Bone Resorption 01/2011 - 04/2006
3	Osteosarcoma (Osteogenic Sarcoma) 01/2015 - 09/2007
3	Osteoporosis 09/2009 - 04/2006
2	Breast Neoplasms (Breast Cancer) 01/2014 - 05/2007
1	HIV Infections (HIV Infection) 09/2015
1	Obesity 07/2013
1	Pediatric Obesity 07/2013
1	Iron Overload 01/2013
1	Adenocarcinoma 08/2011
1	Disease Progression 04/2011
1	Hemochromatosis (Bronze Diabetes) 04/2011
1	Tooth Diseases 07/2010
1	Renal Cell Carcinoma (Grawitz Tumor) 12/2006
1	Hyperglycemia 10/2002

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2013 - 01/2004
4	LigandsIBA 09/2015 - 08/2008
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 01/2011
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2015 - 09/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2015 - 09/2006
3	ElementsIBA 07/2013 - 09/2006
2	OsteoprotegerinIBA 09/2015 - 08/2010
2	KN 93IBA 01/2015 - 09/2007
2	Calcium-Calmodulin-Dependent Protein KinasesIBA 04/2013 - 09/2007
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2013 - 01/2011
2	IronIBA 01/2013 - 04/2011
2	AndrogensIBA 01/2011 - 04/2007
2	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 08/2010 - 08/2008
2	Parathyroid Hormone (Parathormone)IBA 09/2009 - 04/2006
2	Carrier Proteins (Binding Protein)IBA 12/2006 - 09/2006
2	Cyclic AMP (AMP, Cyclic)IBA 12/2006 - 09/2006
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 12/2006 - 09/2006
1	perlecanIBA 03/2016
1	Matrix Metalloproteinases (MMPs)IBA 03/2016
1	cyclo-VEGIIBA 01/2015
1	Protein Isoforms (Isoforms)IBA 01/2014
1	Methylnitronitrosoguanidine (MNNG)IBA 04/2013
1	DNA Repair EnzymesIBA 01/2013
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 08/2011
1	Racemases and Epimerases (Epimerases and Racemases)IBA 08/2011
1	Coenzyme A (CoA)IBA 08/2011
1	Uncoupling Protein 1IBA 04/2011
1	Hemochromatosis ProteinIBA 04/2011
1	CD40 Ligand (CD40L)IBA 01/2011
1	Cadherins (E-Cadherin)IBA 01/2011
1	VimentinIBA 01/2011
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2011
1	Growth Factor ReceptorsIBA 01/2011
1	CytokinesIBA 08/2010
1	Mitochondrial DNA (mtDNA)IBA 01/2009
1	NucleotidesIBA 01/2009
1	LuciferasesIBA 01/2009
1	Fibroblast Growth Factor 1 (FGF-1)IBA 01/2009
1	Diphosphonates (Bisphosphonates)IBA 10/2008
1	AmidesIBA 10/2008
1	Prostate-Specific Antigen (Semenogelase)IBA 10/2008
1	1- ((N- (2,3,4,5,6- pentafluorocinnamoyl)- O- (2,6- dichlorobenzyl))tyrosyl)- 4- (bis(diethoxyphosphono))methylaminiopiperidineIBA 10/2008
1	Tyrosine (L-Tyrosine)FDA Link 10/2008
1	SurvivinIBA 10/2008
1	CalcineurinIBA 11/2007
1	Guanosine Triphosphate (GTP)IBA 09/2007
1	OligonucleotidesIBA 05/2007
1	Matrix Metalloproteinase 13IBA 05/2007
1	honokiolIBA 04/2007
1	Docetaxel (Taxotere)FDA Link 04/2007
1	Biological ProductsIBA 12/2006
1	Phosphotransferases (Kinase)IBA 12/2006
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 09/2006
1	OsteocalcinIBA 09/2006
1	Conditioned Culture MediaIBA 09/2006
1	Liposomes (Liposome)IBA 09/2006
1	Cyclin AIBA 09/2006
1	Cyclin D1IBA 09/2006
1	Small Interfering RNA (siRNA)IBA 09/2006
1	Caspase 3 (Caspase-3)IBA 09/2006
1	Caspase 9IBA 09/2006
1	Explosive Agents (Explosives)IBA 09/2006
1	Integrin-Binding SialoproteinIBA 09/2006
1	CollagenIBA 10/2002
1	Mannitol (Osmitrol)FDA LinkGeneric 10/2002
1	Glucose (Dextrose)FDA LinkGeneric 10/2002
1	p38 Mitogen-Activated Protein KinasesIBA 10/2002

Therapy/Procedure

6	Therapeutics 01/2015 - 04/2007
1	Protective Devices (Safety Device) 07/2013
1	Radiotherapy 01/2013
1	Aftercare (After-Treatment) 10/2008